Recombinant Human CD161/KLRB1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD161 protein Gln67-Ser225 (Accession# Q12918) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3820 |
| 蛋白编号 | Q12918 |
| 预测分子量 | 44.8 kDa |
| SDS-PAGE | 50-68 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD161 (KLRB1) is a clinical diagnostic marker predicting negative course of patients with gliomas. It plays prominent immune‐evading roles in glioma, and the expression of CD161 on CD8+ lymphocytes gradually increases during glioblastoma genesis. CD161 was shown to inhibit natural killer (NK) cell–mediated cytotoxicity of tumor cells, and CLEC2D (alternatively named lectin-like transcript 1; LLT1) was identified as its ligand.
参考文献:
1.Di, Wang et al. Cancer science vol. 113,2 (2022): 756-769. 2.Mathewson, Nathan D et al.Cell vol. 184,5 (2021): 1281-1298.e26. 3.Alvarez Calderon, Francesca et al.Blood vol. 143,12 (2024): 1124-1138.
