Recombinant Human ILT-3/LILRB4 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human ILT-3 protein Gln22-Glu259 (Accession# AAH26309.1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 11006 |
| 蛋白编号 | AAH26309.1 |
| 预测分子量 | 52.3 kDa |
| SDS-PAGE | 55-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
LILRB4 is an inhibitory receptor in the LILR family mainly expressed on normal and malignant human cells of myeloid origin. LILRB4 is activated and subsequently recruits adaptors to cytoplasmic immunoreceptor tyrosine inhibitory motifs to initiate different signaling cascades, thus playing an important role in physiological and pathological conditions, including autoimmune diseases, microbial infections, and cancers.
参考文献:
1. Yang, Xing et al. Nature immunology vol. 26,9 (2025): 1567-1580. 2. Deng, Mi et al. Nature vol. 562,7728 (2018): 605-609. 3. Xie, Li et al. Cell death & disease vol. 15,7 515. 18 Jul. 2024
