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Recombinant Mouse Thrombopoietin protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0678

Print datasheet

Synonyms

Thpo, Mpllg, TPO

验证数据展示

  • Purity of Recombinant Mouse Thrombopoietin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Thrombopoietin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Thrombopoietin protein Ser22-Thr356 (Accession# P40226-1) with a His tag at the C-terminus.
基因ID 21832
蛋白编号 P40226-1
预测分子量 36.7 kDa
SDS-PAGE 60-85 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Thrombopoietin (TPO) is produced in the liver by both parenchymal cells and sinusoidal endothelial cells, as well as in the kidney by proximal convoluted tubule cells. It is a primary regulator of megakaryocyte development and platelet production in mammals. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, as TPO is vital for the maintenance of haematopoietic stem cells, it can truly be described as a pan- haematopoietic cytokine.

参考文献:

1. David J Kuter. et al. (2013). Int J Hematol. 98(1):10-23.
2. Matthew Decker. et al. (2018) Science. 360(6384):106-110.
3. Kenneth Kaushansky. et al. (2006) N Engl J Med. 354(19):2034-45.
4. D Prow. et al. (1998) Oncology (Williston Park). 12(11):1597-604, 1607-8.