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验证数据展示

  • FC experiment of human PBMCs using 98438-1-RR (same clone as 98438-1-PBS)

    FC experiment of human PBMCs using 98438-1-RR (same clone as 98438-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TGFBR2 Rabbit RecAb (98438-1-RR, Clone: 250238A7) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98438-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98438-1-RR (same clone as 98438-1-PBS)

    FC experiment of human PBMCs using 98438-1-RR (same clone as 98438-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TGFBR2 Rabbit RecAb (98438-1-RR, Clone: 250238A7) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98438-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98438-1-PBS

    Affinity and Kinetic Characterization of 98438-1-PBS

    Biolayer interferometry (BLl) kinetic assay of 98438-1-PBS against Human TGFBR2 was performed. The affinity constant is 0.937 nM.

Anti-Human TGFBR2 Rabbit Recombinant Antibody, PBS Only

TGFBR2 Uni-rAb® Recombinant Antibody for FC
Cat No. 98438-1-PBS

产品说明书

CloneNo. 250238A7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

EC:2.7.11.30, TbetaR-II, TGF beta receptor type 2, TGF-beta receptor type II, TGF-beta receptor type-2

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98438-1-PBS targets TGFBR2 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原

CatNo: Eg2943

Product name: Recombinant Human TGFBR2 protein (rFc Tag)(HPLC verified)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 23-159 aa of NM_003242.5

Sequence: TIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transforming growth factor, beta receptor II (70/80kDa)
别名 EC:2.7.11.30, TbetaR-II, TGF beta receptor type 2, TGF-beta receptor type II, TGF-beta receptor type-2
计算分子量65 kDa
GenBank蛋白编号NM_003242.5
基因名称 TGFBR2
Gene ID (NCBI) 7048
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP37173-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TGF beta Receptor II (TGFBR2) is a member of the transforming growth factor-β (TGF-β) superfamily, which are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (PMID: 10974075). TGFBR2 is a serine/threonine kinase and the primary ligand-binding receptor. After binding of the ligand TGF-β1, TGFBR2 forms a heterodimer complex with TGFBR1, causing conformational changes and signal propagation via canonical (SMAD-dependent) and non-canonical (SMAD-independent) routes. Upon translocation into the nucleus, activated SMAD complexes can interact with various transcription factors to control target gene expression (PMID: 31454892).

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