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Species Reactivity
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Conjugate
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验证数据展示

  • FC experiment of human PBMCs using 98240-1-RR

    FC experiment of human PBMCs using 98240-1-RR

    1x10^6 human PBMCs were surface stained with 0.125 ug Anti-Human CD46 Rabbit Recombinant Antibody (98240-1-RR, Clone: 241764C9) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD19. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • FC experiment of human PBMCs using 98240-1-RR

    FC experiment of human PBMCs using 98240-1-RR

    1x10^6 human PBMCs were surface stained with 0.125 ug Anti-Human CD46 Rabbit Recombinant Antibody (98240-1-RR, Clone: 241764C9) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

Anti-Human CD46 Rabbit Recombinant Antibody

CD46 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98240-1-RR

产品说明书

CloneNo. 241764C9

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

MCP, Membrane cofactor protein, MIC10, TLX, TRA2.10

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive FC detected inhuman PBMCs
Planning an IHC experiment? We recommend our IHCeasy CD46 Ready-To-Use IHC Kit. CD46 primary antibody included.

推荐稀释比

应用推荐稀释比
Flow Cytometry (FC)FC : 0.125 ug per 10^6 cells in a 100 µl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98240-1-RR targets CD46 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 CD46 fusion protein Eg1770 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD46 molecule, complement regulatory protein
别名 MCP, Membrane cofactor protein, MIC10, TLX, TRA2.10
计算分子量42kDa
GenBank蛋白编号NM_172351.3
基因名称 CD46
Gene ID (NCBI) 4179
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP15529-11
储存缓冲液 PBS with 0.09% sodium azide, pH 7.3.
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

CD46, also known as Membrane cofactor protein (MCP) or MIC10, is a ubiquitously expressed type type-I transmembrane glycoprotein that acts as a cofactor for complement factor I to mediate inactivation of C3b and C4b deposited on host cells. CD46 is a receptor for a large number of pathogens, including measles virus and adenovirus (PMID: 20941397). CD46 plays a role in linking innate and adaptive immune responses. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations of the CD46 gene have been associated with some diseases including hemolytic uremic syndrome (PMID: 26054645). CD46 is expressed on most cells as four isoforms that are derived via alternative splicing (PMID: 15324743).

实验方案

Product Specific Protocols
FC protocol for CD46 antibody 98240-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols