JAK/STAT Signaling: New Pathway Poster
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JAK/STAT Pathway Overview
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway transmits information from extracellular chemical signals to the nucleus, resulting in DNA transcription and gene expression. JAK belongs to a family of non-receptor protein tyrosine kinases comprising JAK1, JAK2, JAK3, and TYK2. STATs are latent cytoplasmic transcription factors that become activated after recruitment to an activated receptor complex. Seven STAT proteins have been identified, STAT1 to STAT6, including STAT5a and STAT5b, which are encoded by distinct genes (1).
These cytokines and growth factors are responsible for various cellular functions, including proliferation, growth, hematopoiesis, immune response, or biological regulation of stem cells.
Overactivation of the JAK‐STAT pathway can cause cancer by bypassing apoptosis and cell cycle checkpoints. Inhibiting JAK function has been shown to efficiently prevent the uncontrolled growth of cancerous cells and to harness overly active immune cells (2-3).
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Download a JAK-STAT Pathway here |
Related Antibodies
| JAK1 | STAT5A |
| JAK2 | STAT5B |
| STAT1 KO/KD Validated | STAT6 |
| STAT2 | MTOR |
| STAT3 KO/KD Validated | ERK1/2 KO/KD Validated |
| STAT4 | CAMMKK2 KD/KO Validated |
Browse more pathway posters here |
References
1) Biology and significance of the JAK/STAT signalling pathways
2) Dynamics and non-canonical aspects of JAK/STAT signalling.
3) The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours.