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验证数据展示

  • FC experiment of human PBMCs using 98253-1-RR (same clone as 98253-1-PBS)

    FC experiment of human PBMCs using 98253-1-RR (same clone as 98253-1-PBS)

    1x10^6 untreated or PMA and ionomycin treated human PBMCs were surface stained with 0.25 ug Anti-Human CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody (98253-1-RR, Clone: 241831D9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were not fixed. This data was developed using the same antibody clone with 98253-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98253-1-RR (same clone as 98253-1-PBS)

    FC experiment of human PBMCs using 98253-1-RR (same clone as 98253-1-PBS)

    1x10^6 PMA and ionomycin treated human PBMCs were surface stained with 0.25 ug Anti-Human CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody (98253-1-RR, Clone: 241831D9) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody (98253-1-RR, Clone: 241831D9) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98253-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98253-1-RR

    Affinity and Kinetic Characterization of 98253-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98253-1-RR against Human CD30 Ligand/TNFSF8 were performed. The affinity constant is below 1 pM.

Anti-Human CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody, PBS Only

CD30 Ligand/TNFSF8 Uni-rAb® Recombinant Antibody for FC
Cat No. 98253-1-PBS

产品说明书

CloneNo. 241831D9

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD30 L, TNFSF 8, TNFSF8, 241831D9, CD30L

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98253-1-PBS targets CD30 Ligand/TNFSF8 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原

CatNo: Eg2118

Product name: Recombinant Human CD30 Ligand/TNFSF8 protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-N-rFc

Tag: N-rFc

Domain: 63-234 aa of BC093630

Sequence: QRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYLQVAKHLNKTKLSWNKDGILHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKLELLINKHIKKQALVTVCESGMQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor (ligand) superfamily, member 8
别名 CD30 L, TNFSF 8, TNFSF8, 241831D9, CD30L
计算分子量 234 aa, 26 kDa
GenBank蛋白编号BC093630
基因名称 TNFSF8
Gene ID (NCBI) 944
RRIDAB_3745920
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP32971
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD30 Ligand (CD30L), also named as TNFSF8 or CD153, is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) superfamily (PMID: 8391931). It is expressed on the surface of activated T cells, B cells, monocytes, macrophages, eosinophils, neutrophils, and mast cells (PMID: 26090498). CD30L interacts with its receptor, CD30, which is a cell surface protein expressed on a small subset of activated T and B lymphocytes, and a variety of lymphoid neoplasms, with the highest expression in classical Hodgkin lymphoma and anaplastic large cell lymphomas (PMID: 28885612). The CD30/CD30L signaling is involved in pleiotropic downstream effects including differentiation, cell survival and death, NFkB activation, and production of cytokines (PMID: 38534788).

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