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验证数据展示

  • WB analysis using 87458-1-RR (same clone as 87458-1-PBS)

    WB analysis using 87458-1-RR (same clone as 87458-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87458-1-RR (PLAU/uPA antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87458-1-PBS in a different storage buffer formulation.

  • IF Staining of PC-3 using 87458-1-RR (same clone as 87458-1-PBS)

    IF Staining of PC-3 using 87458-1-RR (same clone as 87458-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed PC-3 cells using uPA/Urokinase antibody (87458-1-RR, Clone: 252624A5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 87458-1-PBS in a different storage buffer formulation.

  • Affinity of 87458-1-RR

    Affinity of 87458-1-RR

    Biolayer interferometry (BLl) kinetic assays of 87458-1-RR against Human uPA/Urokinase were performed. The affinity constant is 0.549 nM.

uPA/Urokinase Recombinant monoclonal antibody, PBS Only

uPA/Urokinase Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 87458-1-PBS

产品说明书

CloneNo. 252624A5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

PLAU, UPA, ATF, EC:3.4.21.73, u PA

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87458-1-PBS targets uPA/Urokinase in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg7083

Product name: Recombinant human PLAU/uPA protein

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 21-431 aa of NM_002658.6

Sequence: SNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 plasminogen activator, urokinase
别名 PLAU, UPA, ATF, EC:3.4.21.73, u PA
计算分子量49kDa
观测分子量 49 kDa
GenBank蛋白编号NM_002658.6
基因名称 Urokinase
Gene ID (NCBI) 5328
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP00749-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1 (PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing. Defects in PLAU are the cause of Quebec platelet disorder (QPD).

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