• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human TGF beta 3 protein

Activity

0.14-0.75 ng/mL EC50

Species Reactivity

human,mouse

Purity

>95%

Cat No : HZ-1090

Print datasheet

Synonyms

ARVD, FLJ16571, TGF beta 3, TGF beta3, TGFB3



Technical Specifications

GeneID 7043
Species Human
Expression HEK293
Activity 0.14-0.75 ng/mL EC50
Purity >95%
Endotoxin<1 EU/µg
Accession NumberP17125
Molecular Mass 25 kDa, homodimer, non-glycosylated
Formulation 50 mM NaOAc pH 3.7, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

The transforming growth factor beta-3 (TGFβ-3) protein is found throughout the body and is required for development before birth and throughout life. TGFβ-3 binds to the receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell. As part of the TGF-β a signalling pathway, the TGFβ-3 protein helps to control the growth and cell proliferation. The TGFβ-3 protein is especially abundant in skeletal muscles and plays a key role in their development. The protein is also involved in blood vessels formation, regulation of bone growth, and wound healing (PMID: 25835445; 23824657)

Synonyms

ARVD, FLJ16571, TGF beta 3, TGF beta3, TGFB3

Publications

SpeciesTitle
human

Biochem J

Soluble CD109 binds TGF-β and antagonizes TGF-β signalling and responses.

Authors - CarterLi
human

Front Bioeng Biotechnol

Mechano-Hypoxia Conditioning of Engineered Human Meniscus.

Authors - Alexander R A Szojka
human

Biol Reprod

Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function.

Authors - YangGao
human

PLoS One

Oxygen tension is a determinant of the matrix-forming phenotype of cultured human meniscal fibrochondrocytes.

Authors - Adetola BAdesida
mouse

PLoS One

YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.

Authors - RainerSchmid
human

BMC Musculoskelet Disord

Matrix forming characteristics of inner and outer human meniscus cells on 3D collagen scaffolds under normal and low oxygen tensions.

Authors - RogerCroutze