|Activity||0.14-0.75 ng/mL EC50|
|Molecular Mass||25 kDa, homodimer, non-glycosylated|
|Formulation||50 mM NaOAc pH 3.7, See Certificate of Analysis for details|
Stability and Reconstitution
|Stability and Storage||Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.|
|Reconstitution||Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).|
The transforming growth factor beta-3 (TGFβ-3) protein is found throughout the body and is required for development before birth and throughout life. TGFβ-3 binds to the receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell. As part of the TGF-β a signalling pathway, the TGFβ-3 protein helps to control the growth and cell proliferation. The TGFβ-3 protein is especially abundant in skeletal muscles and plays a key role in their development. The protein is also involved in blood vessels formation, regulation of bone growth, and wound healing (PMID: 25835445; 23824657)
ARVD, FLJ16571, TGF beta 3, TGF beta3, TGFB3
Soluble CD109 binds TGF-β and antagonizes TGF-β signalling and responses.
Front Bioeng Biotechnol
Mechano-Hypoxia Conditioning of Engineered Human Meniscus.
Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function.
Oxygen tension is a determinant of the matrix-forming phenotype of cultured human meniscal fibrochondrocytes.
YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.
BMC Musculoskelet Disord
Matrix forming characteristics of inner and outer human meniscus cells on 3D collagen scaffolds under normal and low oxygen tensions.