Validation Data Gallery
Technical Specifications
| GeneID | 1435 |
| Species | Human |
| Expression | HEK293 |
| Activity | 0.7-4.0 ng/mL |
| Specific Activity | minimally 4.00 x 107 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P09603 |
| Molecular Mass | 19 and 23 kDa reduced, 35 and 40 kDa non-reduced, homodimer, glycosylated |
| Formulation | 1x PBS, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
M-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration and plays a role in lipoprotein clearance (PMID: 29734839; 29679908; 28202039)
Synonyms
CSF 1, CSF1, Lanimostim, M CSF, MCSF, M-CSF
Publications
| Species | Title |
|---|---|
Signal Transduct Target Ther Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer. | |
Cell Metab A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis. | |
Cell Metab Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain | |
Cell Metab Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK | |
