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验证数据展示

  • WB analysis using 88083-1-RR (same clone as 88083-1-PBS)

    WB analysis using 88083-1-RR (same clone as 88083-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 88083-1-RR (CTNND1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. Low expression: HL-60 cells. This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 88083-1-RR (same clone as 88083-1-PBS)

    IHC staining of human colon using 88083-1-RR (same clone as 88083-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 88083-1-RR (p120 Catenin antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with p120 Catenin antibody included
  • IHC staining of human colon using 88083-1-RR (same clone as 88083-1-PBS)

    IHC staining of human colon using 88083-1-RR (same clone as 88083-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 88083-1-RR (p120 Catenin antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with p120 Catenin antibody included
  • IF Staining of MCF-7 using 88083-1-RR (same clone as 88083-1-PBS)

    IF Staining of MCF-7 using 88083-1-RR (same clone as 88083-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using p120 Catenin antibody (88083-1-RR, Clone: 260247D5 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 88083-1-PBS in a different storage buffer formulation.

p120 Catenin Recombinant monoclonal antibody, PBS Only

p120 Catenin Uni-rAb® Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 88083-1-PBS

产品说明书

CloneNo. 260247D5

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

CTNND1, Cadherin-associated Src substrate, CAS, Catenin delta 1, Catenin delta-1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy p120 Catenin Ready-To-Use IHC Kit. p120 Catenin primary antibody included.

产品信息

88083-1-PBS targets p120 Catenin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag2824

Product name: Recombinant human CTNND1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 546-830 aa of BC010501

Sequence: GYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNKTLDRSGDLGDMEPLKGTTPLMQKI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 catenin (cadherin-associated protein), delta 1
别名 CTNND1, Cadherin-associated Src substrate, CAS, Catenin delta 1, Catenin delta-1
计算分子量 948 aa, 105 kDa
观测分子量75-120 kDa
GenBank蛋白编号BC010501
基因名称 p120 Catenin
Gene ID (NCBI) 1500
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO60716
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins (PMID: 9653641). p120 catenin, also called p120 ctn or catenin delta-1(CTNND1), regulates cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins. p120 catenin is a tyrosine kinase substrate implicated in cell transformation by SRC, as well as in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor, and the CSF1 receptor. Different expression patterns of p120 catenin in lobular and ductal carcinomas of the breast have been reported: membrane stain for ductal carcinoma and cytoplasmic stain for lobular carcinoma (PMID: 24966968). Different isoforms of p120 catenin are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons (PMID: 19150613).

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