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验证数据展示

  • WB analysis using 66576-1-Ig (same clone as 66576-1-PBS)

    WB analysis using 66576-1-Ig (same clone as 66576-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66576-1-Ig (c-Cbl antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66576-1-Ig (same clone as 66576-1-PBS)

    IHC staining of human tonsillitis using 66576-1-Ig (same clone as 66576-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66576-1-Ig (CBL antibody) at dilution of 1:600 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CBL antibody included
  • IHC staining of human tonsillitis using 66576-1-Ig (same clone as 66576-1-PBS)

    IHC staining of human tonsillitis using 66576-1-Ig (same clone as 66576-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66576-1-Ig (CBL antibody) at dilution of 1:600 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CBL antibody included
  • Featured Product
  • KD/KO验证

c-Cbl Monoclonal antibody, PBS Only

c-Cbl Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66576-1-PBS

产品说明书

CloneNo. 2F6D1

宿主/亚型

Mouse / IgG1

种属反应性

Human

应用

WB, IHC, Indirect ELISA

别名

C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy CBL Ready-To-Use IHC Kit. CBL primary antibody included.

产品信息

66576-1-PBS targets c-Cbl in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human
免疫原

CatNo: Ag23033

Product name: Recombinant human CBL protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 578-906 aa of BC132733

Sequence: LPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 Cas-Br-M (murine) ecotropic retroviral transforming sequence
别名 C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55
计算分子量 906 aa, 100 kDa
观测分子量 100-120 kDa
GenBank蛋白编号BC132733
基因名称 CBL
Gene ID (NCBI) 867
RRIDAB_2881936
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP22681
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

c-Cbl (Casitas B-lineage lymphoma) is a critical regulator that controls immature or follicular helper T cell development, B cell development, immune tolerance, angiogenesis, or tumorigenesis (PMID: 33962939). c-Cbl also plays a pivotal role in regulating dendritic cell (DC) function via negatively modulating IL-12 production after Toll-like receptor (TLR) stimulation (PMID: 21799517).

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