BLI analysis of the capture of varying concentrations of HumanKine IL-34 (HZ-1316) by biotinylated anti-IL-34 VHH (IL34-b). Please note the higher apparent affinity owing to avidity effects (dimerization of the cytokine).
ELISA analysis of the capture of varying concentrations of HumanKine IL-34 (HZ-1316) by biotinylated anti-IL-34 VHH (IL34-b). Detection via mouse IgG1 ABIN969216.

ChromoTek anti-IL34 recombinant VHH, biotinylated

Cat No. IL34-b

Host/Type

Alpaca VHH

Reactivity

Human

Applications

BLI, SPR, ELISA

Conjugate

Biotin

Synonyms

IL34 VHH, IL34 single domain antibody (sdAb), Interleukin-34, IL34

规格	价格	库存

IL34-b is a recombinant mono-biotinylated anti IL34 Nanobody (VHH), suitable for ELISA, SPR, and BLI applications.

Applications	BLI, SPR, ELISA
Reactivity	Human
Conjugate	Biotin
Type	Nanobody
Class	Recombinant
Host	Alpaca
Affinity	330 nM
Molecular Weight	15.0 kDa
Form	Liquid
RRID	AB_3665405
Storage Buffer	10 mM HEPES pH 7.0, 500 mM NaCl, 5 mM EDTA, 0.09% sodium azide
Storage Condition	Store at -20°C
Shipping	ambient
Background	IL-34 is a 6-α-helix, proinflammatory cytokine that serves as a ligand for colony-stimulating factor-1 receptor (CSF1R). It is expressed most abundantly by spleen cells. It primarily stimulates human peripheral blood monocyte proliferation and macrophage colony formation. It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to mark the progression of these diseases (PMID: 22579672, 27577879, 31940023).

SDS
IL34-b_SDS_anti-IL34 recombinant VHH, biotinylated (EN)