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ZNF746 Polyclonal antibody

ZNF746 Polyclonal Antibody for WB, ELISA
Cat No. 24543-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human and More (2)

应用

WB, ELISA and More (2)

Zinc finger protein 746, Parkin-interacting substrate, PARIS, FLJ31413

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格价格库存


经过测试的应用

Positive WB detected inHEK-293 cells, HEK-293T cells
Planning an IHC experiment? We recommend our IHCeasy ZNF746 Ready-To-Use IHC Kit. ZNF746 primary antibody included.

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

24543-1-AP targets ZNF746 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
文献引用应用WB, IHC, IF
经测试反应性 human
文献引用反应性human, mouse, rat
免疫原

CatNo: Ag21566

Product name: Recombinant human ZNF746 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 186-531 aa of BC068505

Sequence: MQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRML

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 zinc finger protein 746
别名 Zinc finger protein 746, Parkin-interacting substrate, PARIS, FLJ31413
计算分子量 644 aa, 69 kDa
观测分子量 85-95 kDa
GenBank蛋白编号BC068505
基因名称 ZNF746
Gene ID (NCBI) 155061
RRIDAB_2879598
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6NUN9
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN (PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).

实验方案

Product Specific Protocols
WB protocol for ZNF746 antibody 24543-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseWB

Neuron

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.

Authors - Nikhil Panicker
  • KO Validated
human,mouseWB

Sci Adv

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.

Authors - Sheila K Pirooznia
mouseWB

Brain

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.

Authors - Saurav Brahmachari
human,mouseWB,IF

Brain

Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.

Authors - Hyojung Kim
mouseWB

Front Aging Neurosci

Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice

Authors - Hyojung Kim
human,mouseWB,IHC

Biochem Biophys Res Commun

ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.

Authors - Hanna Kim
  • KO Validated
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