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验证数据展示

  • WB analysis using 33685-1-AP (same clone as 33685-1-PBS)

    WB analysis using 33685-1-AP (same clone as 33685-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33685-1-AP (YKT6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33685-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 33685-1-AP (same clone as 33685-1-PBS)

    IHC staining of human ovary tumor using 33685-1-AP (same clone as 33685-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 33685-1-AP (YKT6 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 33685-1-PBS in a different storage buffer formulation.

  • IF Staining of A431 using 33685-1-AP (same clone as 33685-1-PBS)

    IF Staining of A431 using 33685-1-AP (same clone as 33685-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using YKT6 antibody (33685-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 33685-1-PBS in a different storage buffer formulation.

  • IF Staining of U-251 using 33685-1-AP (same clone as 33685-1-PBS)

    IF Staining of U-251 using 33685-1-AP (same clone as 33685-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U-251 cells using YKT6 antibody (33685-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 33685-1-PBS in a different storage buffer formulation.

YKT6 Polyclonal antibody, PBS Only

YKT6 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 33685-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

EC:2.3.1.-, Synaptobrevin homolog YKT6, YKT6 V-SNARE Homolog

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

33685-1-PBS targets YKT6 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag38740

Product name: Recombinant human YKT6 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 111-198 aa of BC007319

Sequence: PVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 YKT6 v-SNARE homolog (S. cerevisiae)
别名 EC:2.3.1.-, Synaptobrevin homolog YKT6, YKT6 V-SNARE Homolog
计算分子量 22 kDa
观测分子量25 kDa
GenBank蛋白编号BC007319
基因名称 YKT6
Gene ID (NCBI) 10652
RRIDAB_3743050
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDO15498
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

YKT6 is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) that plays a central role in membrane fusion in eukaryotic cells. It is primarily localized in the cytoplasm and, through its unique dual lipidation modification (palmitoylation and farnesylation), can associate with various organelle membranes, such as the Golgi apparatus, endosomes, and vesicles. By forming stable trans-SNARE complexes with other SNARE proteins (e.g., Syntaxin and SNAP-25 family members) on target membranes, YKT6 provides the driving force for membrane fusion, thereby facilitating intracellular trafficking. This protein is essential for maintaining organelle integrity, autophagy, and secretory pathways. Studies have shown that dysfunction of YKT6 is associated with various diseases, including cancer, neurodegenerative disorders, and metabolic abnormalities, making it a potential target for drug development.

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