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验证数据展示

  • WB analysis using 67274-1-Ig (same clone as 67274-1-PBS)

    WB analysis using 67274-1-Ig (same clone as 67274-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67274-1-Ig (WWP2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67274-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 67274-1-Ig (same clone as 67274-1-PBS)

    IHC staining of human pancreas cancer using 67274-1-Ig (same clone as 67274-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 67274-1-Ig (WWP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67274-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 67274-1-Ig (same clone as 67274-1-PBS)

    IHC staining of human pancreas cancer using 67274-1-Ig (same clone as 67274-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 67274-1-Ig (WWP2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67274-1-PBS in a different storage buffer formulation.

WWP2 Monoclonal antibody, PBS Only

WWP2 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 67274-1-PBS

产品说明书

CloneNo. 2C9B4

宿主/亚型

Mouse / IgG1

种属反应性

Human, Rat

应用

WB, IHC, Indirect ELISA

别名

AIP2, WW domain containing protein 2, WWP2, WWp2 like

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

67274-1-PBS targets WWP2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, Rat
免疫原

CatNo: Ag2835

Product name: Recombinant human WWP2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-355 aa of BC013645

Sequence: MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRT

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 WW domain containing E3 ubiquitin protein ligase 2
别名 AIP2, WW domain containing protein 2, WWP2, WWp2 like
计算分子量 870 aa, 99 kDa
观测分子量 100-115 kDa
GenBank蛋白编号BC013645
基因名称 WWP2
Gene ID (NCBI) 11060
RRIDAB_2882543
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDO00308
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

WWP2 (WW domain-containing protein 2) is also named as AIP2 and belongs to the NEDD4-like protein family. It functions as an E3 ubiquitin ligase for PTEN that plays a vital role in tumour-cell survival and is also involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes (PMID:21532586). WWP2, which specifically interacted with ES cell-specific transcription factor Oct-4 and promoted its ubiquitination both in vitro and in vivo, is a ubiquitously expressed protein and exists in both cytoplasmic and nuclear compartments in ES cells (PMID:15047715).

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