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验证数据展示

  • FC experiment of Transfected CHO using 98753-3-RR (same clone as 98753-3-PBS)

    FC experiment of Transfected CHO using 98753-3-RR (same clone as 98753-3-PBS)

    1x10^6 CHO cells or VHL transfected CHO cells were intracellularly stained with 0.25 ug Anti-Human VHL Rabbit RecAb (98753-3-RR, Clone: 251968A5) or 0.25 ug Isotype Control, and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00017). This data was developed using the same antibody clone with 98753-3-PBS in a different storage buffer formulation.

  • FC experiment of Transfected CHO using 98753-3-RR (same clone as 98753-3-PBS)

    FC experiment of Transfected CHO using 98753-3-RR (same clone as 98753-3-PBS)

    x10^6 CHO cells or VHL transfected CHO cells were intracellularly stained with 0.25 ug Anti-Human VHL Rabbit RecAb (98753-3-RR, Clone:251968A5) (red) or 0.25 ug Isotype Control (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00017). This data was developed using the same antibody clone with 98753-3-PBS in a different storage buffer formulation.

Anti-Human VHL Rabbit Recombinant Antibody, PBS Only

VHL Uni-rAb® Recombinant Antibody for FC (Intra)
Cat No. 98753-3-PBS

产品说明书

CloneNo. 251968A5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

别名

Protein G7, pVHL, RCA1, VHL 1, VHL1

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy VHL Ready-To-Use IHC Kit. VHL primary antibody included.

产品信息

98753-3-PBS targets VHL in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原

CatNo: Eg6405

Product name: Recombinant human VHL protein

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 1-213 aa of NM_000551.4

Sequence: MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 von Hippel-Lindau tumor suppressor
别名 Protein G7, pVHL, RCA1, VHL 1, VHL1
计算分子量24 kDa
GenBank蛋白编号NM_000551.4
基因名称 VHL
Gene ID (NCBI) 7428
RRIDAB_3746321
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP40337
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

VHL (von Hippel-Lindau tumor suppressor) gene was identified as the tumor suppressor gene whose germ line mutations are associated with the inherited von Hippel-Lindau cancer syndrome (PMID: 8603073, 10722748). VHL patients develop a wide variety of tumors including retinal angioma, central nervous system hemangioblastoma, pheochromocytoma, and renal clear cell carcinoma (PMID: 10722748). VHL localizes predominantly to the cytoplasmic compartment but engages in a dynamic nuclear-cytoplasmic shuttle (PMID: 8700833, 9891082, 12101228).

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