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USP38 Polyclonal antibody

USP38 Polyclonal Antibody for WB, IP, ELISA
Cat No. 17767-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human and More (2)

应用

WB, IP, ELISA and More (3)

Ubiquitin thiolesterase 38, Ubiquitin carboxyl-terminal hydrolase 38, KIAA1891, HP43.8KD, EC:3.4.19.12

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inHEK-293T cells
Positive IP detected inK-562 cells
Planning an IHC experiment? We recommend our IHCeasy USP38 Ready-To-Use IHC Kit. USP38 primary antibody included.

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:200-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

17767-1-AP targets USP38 in WB, IHC, IF, IP, CoIP, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IP, ELISA Application Description
文献引用应用WB, IHC, IF, IP, CoIP
经测试反应性 human
文献引用反应性human, mouse, rat
免疫原 USP38 fusion protein Ag12172 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ubiquitin specific peptidase 38
别名 Ubiquitin thiolesterase 38, Ubiquitin carboxyl-terminal hydrolase 38, KIAA1891, HP43.8KD, EC:3.4.19.12
计算分子量 1042 aa, 117 kDa
观测分子量 117 kDa
GenBank蛋白编号BC068975
基因名称 USP38
Gene ID (NCBI) 84640
RRIDAB_2213383
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8NB14
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Ubiquitin specific peptidase 38 (USP38) is a negative regulator of type I IFN signaling. USP38 can strongly induced the degradation of the active form of TBK1 after viral infection. USP38 may play a critical role in the maintenance of the balance between innate immune responses and tolerance through dynamic ubiquitin editing of TBK1 in response to viral infection and perhaps other infectious diseases or cancer. (PMID:27692986)

实验方案

Product Specific Protocols
WB protocol for USP38 antibody 17767-1-APDownload protocol
IP protocol for USP38 antibody 17767-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseWB

J Exp Med

USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.

Authors - Siyuan Chen
  • KO Validated
humanIHC,WB,CoIP

Oncogenesis

USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.

Authors - Wei Zhan
  • KD Validated
humanWB,IHC,IP

Am J Cancer Res

Ubiquitin specific peptidase 38 promotes the progression of gastric cancer through upregulation of fatty acid synthase.

Authors - Zhi Zheng
  • KD Validated
humanWB,IF,CoIP

J Biol Chem

ADAR promotes USP38 auto-deubiquitylation and stabilization in an RNA editing-independent manner in Esophageal Squamous Cell Carcinoma

Authors - Qingyong Hu
humanWB

Int J Biochem Cell Biol

The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.

Authors - Zhijun Xu
mouse,ratWB,IP,IF

Mol Med

USP38 exacerbates pressure overload-induced left ventricular electrical remodeling

Authors - Yucheng Pan
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