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验证数据展示

  • WB analysis using 83709-1-RR (same clone as 83709-1-PBS)

    WB analysis using 83709-1-RR (same clone as 83709-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83709-1-RR (ULBP2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83709-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 83709-1-RR (same clone as 83709-1-PBS)

    WB analysis of Jurkat using 83709-1-RR (same clone as 83709-1-PBS)

    WB result of ULBP2 antibody (83709-1-RR; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ULBP2 transfected Jurkat cells. This data was developed using the same antibody clone with 83709-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 83709-1-RR (same clone as 83709-1-PBS)

    IHC staining of human colon cancer using 83709-1-RR (same clone as 83709-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 83709-1-RR (ULBP2 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83709-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ULBP2 antibody included
  • IHC staining of human colon cancer using 83709-1-RR (same clone as 83709-1-PBS)

    IHC staining of human colon cancer using 83709-1-RR (same clone as 83709-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 83709-1-RR (ULBP2 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83709-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ULBP2 antibody included
  • Affinity and Kinetic Characterization of 83709-1-RR

    Affinity and Kinetic Characterization of 83709-1-RR

    Biolayer interferometry (BLl) kinetic assays of 83709-1-RR against Human ULBP2 were performed. The affinity constant is below 1 pM.

  • Featured Product
  • KD/KO验证

ULBP2 Recombinant monoclonal antibody, PBS Only

ULBP2 Uni-rAb® Recombinant Antibody for WB, IHC, ELISA
Cat No. 83709-1-PBS

产品说明书

CloneNo. 240413A6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, ELISA

别名

240413A6, ALCAN alpha, ALCAN-alpha, N2DL2, N2DL-2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy ULBP2 Ready-To-Use IHC Kit. ULBP2 primary antibody included.

产品信息

83709-1-PBS targets ULBP2 in WB, IHC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg0858

Product name: Recombinant Human ULBP2 protein (His Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-6*HIS

Domain: 26-217 aa of NM_025217.4

Sequence: GRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 UL16 binding protein 2
别名 240413A6, ALCAN alpha, ALCAN-alpha, N2DL2, N2DL-2
计算分子量27 kDa
观测分子量30 kDa
GenBank蛋白编号NM_025217.4
基因名称 ULBP2
Gene ID (NCBI) 80328
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ9BZM5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NKG2D is an activating cell surface receptor that is predominantly expressed on cytotoxic immune cells. NKG2D recognizes a wide range of ligands. In humans, the NKG2D ligand (NKG2DL) includes MICA, MICB, and six members of the ULBP family (ULBP1-6) (PMID: 29568297; 30813924). ULBPs are MHC class I-related molecules (PMID: 11239445). ULBP2 contains two Ig-like domains, the alpha-1 and alpha-2 domains characteristic of the MHC class I family, but lacks the alpha-3 domain. It can be expressed as either a transmembrane or GPI-linked protein, or released from the cell surface (PMID: 21224393; 24614922). ULBP2 binds and activates the NKG2D, mediating the recruitment and activation of NK cells.

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