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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 80878-6-RR (same clone as 80878-6-PBS)

    WB analysis using 80878-6-RR (same clone as 80878-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 80878-6-RR (TrkB antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80878-6-PBS in a different storage buffer formulation.

  • IP experiment of mouse cerebellum using 80878-6-RR (same clone as 80878-6-PBS)

    IP experiment of mouse cerebellum using 80878-6-RR (same clone as 80878-6-PBS)

    IP result of anti-TrkB (IP:80878-6-RR, 4ug; Detection:80878-6-RR 1:4000) with mouse cerebellum tissue lysate 2000 ug. This data was developed using the same antibody clone with 80878-6-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 80878-6-RR (same clone as 80878-6-PBS)

    IHC staining of rat brain using 80878-6-RR (same clone as 80878-6-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 80878-6-RR (TrkB antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80878-6-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 80878-6-RR (same clone as 80878-6-PBS)

    IHC staining of rat brain using 80878-6-RR (same clone as 80878-6-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 80878-6-RR (TrkB antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80878-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 80878-6-RR

    Affinity and Kinetic Characterization of 80878-6-RR

    Biolayer interferometry (BLl) kinetic assays of 80878-6-RR against Human TrkB were performed. The affinity constant is below 1 pM.

TrkB Recombinant antibody, PBS Only

TrkB Uni-rAbTM Recombinant Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 80878-6-PBS

产品说明书

CloneNo. 241473G5

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

NTRK2, 241473G5, BDNF/NT-3 growth factors receptor, GP145 TrkB, GP145-TrkB

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

80878-6-PBS targets TrkB in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 TrkB fusion protein Ag3790 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 neurotrophic tyrosine kinase, receptor, type 2
别名 NTRK2, 241473G5, BDNF/NT-3 growth factors receptor, GP145 TrkB, GP145-TrkB
计算分子量 822 aa, 92 kDa
观测分子量 90-95 kDa
GenBank蛋白编号BC031835
基因名称 TrkB
Gene ID (NCBI) 4915
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ16620
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tropomyosin-related kinase B (TrkB) is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. It is a single-pass type 1 membrane protein consisting of three domains: an extracellular ligand binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. TrkB is primarily expressed in the central and peripheral nervous systems. TrkB plays an important role in neural development and maintenance by regulating neuronal differentiation, proliferation, survival, migration, neurogenesis, and plasticity. This antibody raised against 41-433aa of human TrkB recognizes the full-length form (140-145 kDa) and truncated form (90-95 kDa) of TrkB (PMID: 23526925; 21039416).