验证数据展示
经过测试的应用
| Positive IF/ICC detected in | bEnd.3 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:125-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
84469-5-RR targets Tie-2 in IF/ICC, ELISA applications and shows reactivity with mouse samples.
| 经测试应用 | IF/ICC, ELISA Application Description |
| 经测试反应性 | mouse |
| 免疫原 | FusionProtein 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | endothelial-specific receptor tyrosine kinase |
| 别名 | HYK, Endothelial tyrosine kinase, EC:2.7.10.1, CD202b, Angiopoietin-1 receptor |
| 计算分子量 | 126kDa |
| GenBank蛋白编号 | NM_001290549.1 |
| 基因名称 | Tek |
| Gene ID (NCBI) | 21687 |
| RRID | AB_3671993 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | Q02858 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Tie-2, or TEK, is a receptor tyrosine kinase (RTK) specifically expressed in endothelial cells. It plays a crucial role in angiogenesis, forming new blood vessels, and maintaining vascular stability. Tie-2 is a member of the Tie receptor family, characterized by the presence of immunoglobulin and epidermal growth factor (EGF) homology domains. Tie-2 plays a significant role in several vascular diseases, including vascular malformations like venous malformations. It is also implicated in pathological vascular remodeling associated with tumor growth, where it is often overexpressed in tumor vessels.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for Tie-2 antibody 84469-5-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |