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TWEAKR Polyclonal antibody

TWEAKR Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat No : 19836-1-AP

Print datasheet

Synonyms

CD266, FGF inducible 14, FN14, TNFRSF12A, Tweak receptor, TWEAKR

验证数据展示

  • IHC staining of mouse heart using 19836-1-AP

    IHC staining of mouse heart using 19836-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 19836-1-AP (TWEAKR antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive IHC detected inmouse heart tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

19836-1-AP targets TWEAKR in IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IHC, ELISA
Tested Reactivity human, mouse, rat
Immunogen TWEAKR fusion protein Ag13823 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name tumor necrosis factor receptor superfamily, member 12A
Synonyms CD266, FGF inducible 14, FN14, TNFRSF12A, Tweak receptor, TWEAKR
Calculated Molecular Weight 129 aa, 14 kDa
GenBank Accession NumberBC002718
Gene Symbol TNFRSF12A
Gene ID (NCBI) 51330
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9NP84
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TweakR (Fn14, TNFRSF12A) is a member of the TNF receptor superfamily which is activated by its ligand, the cytokine TWEAK (TNFSF12). TweakR is the smallest member of the TNFR superfamily . TweakR was first described as an FGF-inducible gene which played a role in fibroblast adhesion and migration . Subsequently, the induction of TweakR expression by other growth factors and/or upon tissue injury was observed in multiple cell types, including hepatocytes, endothelial cells, adipocytes, and cardiomyocytes. (PMID: 23073510, PMID: 24409185)

实验方案

Product Specific Protocols
IHC protocol for TWEAKR antibody 19836-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols