验证数据展示
产品信息
11538-1-AP targets TUSC2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 | TUSC2 fusion protein Ag2118 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | tumor suppressor candidate 2 |
| 别名 | PDAP2, PAP, LGCC, Fus-1 protein, FUS1 |
| 计算分子量 | 12 kDa |
| 观测分子量 | 10-12 kDa |
| GenBank蛋白编号 | BC023976 |
| 基因名称 | TUSC2 |
| Gene ID (NCBI) | 11334 |
| RRID | AB_10699869 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O75896 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
FUS1 (or TUSC2) gene is a highly conserved lung cancer candidate gene, which was identified in the 120 kb 3p21.3 critical region contained in nested lung and breast cancer homozygous deletions. Overexpression of FUS1 gene leads to G1 arrest and growth inhibition of lung cancer cells (PMID: 11593436). The encoded Fusion-1 protein was down-regulated, mutated or lost in the majority of inflammatory thoracic malignancies. It has been evidenced that Fusion-1 establishes its immune- and tumour-suppressive activities via regulation of mitochondrial homeostasis (PMID: 22513871). In addition, myristoylation is found to be required for Fusion-1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer and a role for deficient posttranslational modification in tumor suppressor-gene-mediated carcinogenesis (PMID: 15126327).