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验证数据展示

  • WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

    WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84634-1-RR (TTBK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 84634-1-RR (same clone as 84634-1-PBS)

    WB analysis of HeLa using 84634-1-RR (same clone as 84634-1-PBS)

    WB result of TTBK2 antibody (84634-1-RR; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTBK2 transfected HeLa cells. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84634-1-RR

    Affinity and Kinetic Characterization of 84634-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84634-1-RR against Human TTBK2 were performed. The affinity constant is 0.14 nM.

  • Featured Product
  • KD/KO验证

TTBK2 Recombinant monoclonal antibody, PBS Only

TTBK2 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 84634-1-PBS

产品说明书

CloneNo. 241456B4

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

241456B4, EC:2.7.11.1, KIAA0847, SCA11, tau tubulin kinase 2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy TTBK2 Ready-To-Use IHC Kit. TTBK2 primary antibody included.

产品信息

84634-1-PBS targets TTBK2 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag7108

Product name: Recombinant human TTBK2 protein

Source: e coli.-derived, T-HIS

Tag: 6*His

Domain: 1-354 aa of BC071556

Sequence: MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tau tubulin kinase 2
别名 241456B4, EC:2.7.11.1, KIAA0847, SCA11, tau tubulin kinase 2
计算分子量 137 kDa
观测分子量 137-150 kDa
GenBank蛋白编号BC071556
基因名称 TTBK2
Gene ID (NCBI) 146057
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ6IQ55
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).

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