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验证数据展示

  • IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

    IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

    IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

  • IF Staining of SH-SY5Y using 12813-1-AP (same clone as 12813-1-PBS)

    IF Staining of SH-SY5Y using 12813-1-AP (same clone as 12813-1-PBS)

    Immunofluorescent analysis of SH-SY5Y cells using 12813-1-AP (TRPM8 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG. This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

TRPM8 Polyclonal antibody, PBS Only

TRPM8 Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 12813-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IF/ICC, Indirect ELISA

别名

LTrpC 6, LTrpC6, LTrpC-6, Trp p8, TRPP8

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12813-1-PBS targets TRPM8 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag3483

Product name: Recombinant human TRPM8 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 3-192 aa of BC001135

Sequence: SFLPVHTIVLIRENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transient receptor potential cation channel, subfamily M, member 8
别名 LTrpC 6, LTrpC6, LTrpC-6, Trp p8, TRPP8
计算分子量 1104 aa, 128 kDa
GenBank蛋白编号BC001135
基因名称 TRPM8
Gene ID (NCBI) 79054
RRIDAB_2877883
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ7Z2W7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TRPM8, also known as CMR1 (cold-menthol receptor-1), is a nonselective cation channel activated by cold and the cooling substances menthol and icilin (PMID: 11893340; 11882888). It serves as a neuronal sensor of cold temperatures. Functioning TRPM8 channels are required for behavioral responses to innocuous cool, noxious cold, injury-evoked cold hypersensitivity, and cooling-mediated analgesia (PMID: 17538622; 21438154; 16920620; 21984952). Additionally, TRPM8 has also been reported to be involved in thermoregulation and the regulation of basal tear flow (PMID: 21407809; 21076394). TRPM8 is expressed extensively in sensory nerves, human prostate and overexpressed in a variety of cancers including prostate, breast, lung, colon and skin melanomas (PMID: 11325849; 20816009).

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