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验证数据展示

  • WB analysis using 21985-1-AP (same clone as 21985-1-PBS)

    WB analysis using 21985-1-AP (same clone as 21985-1-PBS)

    HEK-293 cells( total protein heated at 100℃, membrane protein incubated at 37℃) were subjected to SDS PAGE followed by western blot with 21985-1-AP (TRPM4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21985-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 21985-1-AP (same clone as 21985-1-PBS)

    IHC staining of mouse brain using 21985-1-AP (same clone as 21985-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21985-1-AP (TRPM4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21985-1-PBS in a different storage buffer formulation.

TRPM4 Polyclonal antibody, PBS Only

TRPM4 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 21985-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

21985-1-PBS targets TRPM4 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag17132

Product name: Recombinant human TRPM4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC132727

Sequence: MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transient receptor potential cation channel, subfamily M, member 4
别名
计算分子量 1214 aa, 134 kDa
观测分子量130~150 kDa
GenBank蛋白编号BC132727
基因名称 TRPM4
Gene ID (NCBI) 54795
RRIDAB_2935456
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8TD43
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TRPM4 is a Calcium-activated nonselective cation channel. It is activated by increase in intracellular Ca2+, mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. TRPM4 participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. It's also involved in myogenic constriction of cerebral arteries.

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