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验证数据展示

  • WB analysis using 20948-1-AP (same clone as 20948-1-PBS)

    WB analysis using 20948-1-AP (same clone as 20948-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20948-1-AP (TRIM52 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20948-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary cancer using 20948-1-AP (same clone as 20948-1-PBS)

    IHC staining of human ovary cancer using 20948-1-AP (same clone as 20948-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 20948-1-AP (TRIM52 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20948-1-PBS in a different storage buffer formulation.

TRIM52 Polyclonal antibody, PBS Only

TRIM52 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20948-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

RNF102, tripartite motif containing 52

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

20948-1-PBS targets TRIM52 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag15064

Product name: Recombinant human TRIM52 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-297 aa of BC007372

Sequence: MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCVTQLWSKEDEEDQNEEEDEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDDELWLGDSGITNWDNVDYMWDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDEDEDEELYPDIHPPPSLPLPGQFTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRGNRSNDQGMCFKHQEALKLFCEVDKEAICVVCRESRSHKQHSVLPLEEVVQEYQEIKLETTLVGILQIEQESIHSKAYNQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 tripartite motif-containing 52
别名 RNF102, tripartite motif containing 52
计算分子量 297 aa, 35 kDa
观测分子量35 kDa
GenBank蛋白编号BC007372
基因名称 TRIM52
Gene ID (NCBI) 84851
RRIDAB_3742009
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96A61
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TRIM52 (Tripartite motif 52) is a member of the family of highly conserved RBCC (a RING-finger, two B-boxes, and a predicted alpha-helical Coiled-Coil domain were linked to the N-terminal region in sequence) proteins with more than 70 isoforms, which plays an important role in tumorigenesis through different signaling pathways (PMID: 35837156). TRIM52 promotes tumorigenesis in ovarian cancer by activating the nuclear factor (NF)-κB signaling pathway. Knocking-down of TRIM52 in ovarian cancer cells suppresses cell invasion, cell migration and cell proliferation, while inducing apoptosis (PMID: 30918473, 28073078).

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