验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IHC | See 1 publications below |
产品信息
10083-2-AP targets TRAF4 in WB, IHC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human |
| 文献引用反应性 | human |
| 免疫原 | TRAF4 fusion protein Ag0121 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | TNF receptor-associated factor 4 |
| 别名 | CART1, MLN 62, MLN62, RING finger protein 83, RNF83, TRAF4 |
| 计算分子量 | 54 kDa |
| GenBank蛋白编号 | BC001769 |
| 基因名称 | TRAF4 |
| Gene ID (NCBI) | 9618 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9BUZ4 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TRAF4 is the fourth member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily. TRAF1 and TRAF2 are two related proteins that form a heterodimeric complex that associates with the cytoplasmic domain of the TNF-receptor type 2. The third member TRAF3 associates with the cytoplasmic domain of CD40. TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-KAPPA B activation. This protein also binds to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. TRAF4 thus, is thought to be involved in the oxidative activation of MAPK8/JNK.
发表文章
| Species | Application | Title |
|---|---|---|
Front Oncol Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis | ||
Cell Death Dis Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness. |