验证数据展示
产品信息
24760-1-PBS targets TPOR/MPL in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag19035 Product name: Recombinant human MPL protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 27-379 aa of BC153092 Sequence: DVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYL 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | myeloproliferative leukemia virus oncogene |
| 别名 | CD110, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, Thrombopoietin receptor |
| 计算分子量 | 635 aa, 71 kDa |
| 观测分子量 | 84 kDa, 74 kDa |
| GenBank蛋白编号 | BC153092 |
| 基因名称 | MPL |
| Gene ID (NCBI) | 4352 |
| RRID | AB_2879709 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P40238 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The TPOR/MPL protein (thrombopoietin receptor, also known as myeloproliferative leukemia protein) is a type I transmembrane receptor of the hematopoietic growth factor receptor family. It primarily serves as the specific receptor for thrombopoietin (TPO) and regulates hematopoietic stem cell self-renewal, megakaryocyte differentiation, and platelet production by activating multiple downstream signaling pathways including JAK/STAT, PI3K/AKT, and MAPK, thereby playing a central role in maintaining normal hematopoietic homeostasis in the body.
