验证数据展示
产品信息
88228-1-PBS targets TMEM219 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Eg10278 Product name: Recombinant human TMEM219 protein Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 39-204 aa of NM_001083613.2 Sequence: SFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSR 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | transmembrane protein 219 |
| 别名 | IGFBP-3R, Insulin-like growth factor-binding protein 3 receptor, Transmembrane protein 219 |
| 计算分子量 | 26 kDa |
| 观测分子量 | 26~30 kDa |
| GenBank蛋白编号 | NM_001083613.2 |
| 基因名称 | TMEM219 |
| Gene ID (NCBI) | 124446 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q86XT9 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TMEM219, also known as IGFBP-3R (Insulin-like growth factor-binding protein 3 receptor), is a recently discovered death receptor, which induces cell apoptosis by a Caspase-8-dependent mechanism, through the binding with its ligand, the Insulin-like growth factors binding protein 3 (IGFBP3). TMEM219 was one of the most highly expressed and ranked the third most abundant beta-cell receptor. Increased TMEM219 expression was primarily evident in intestinal cells cultured with inflammatory cytokines and it was associated with higher cell death
