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验证数据展示

  • WB analysis using 17455-1-AP (same clone as 17455-1-PBS)

    WB analysis using 17455-1-AP (same clone as 17455-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17455-1-AP (TMEM120A antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17455-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 17455-1-AP (same clone as 17455-1-PBS)

    WB analysis of HEK-293 using 17455-1-AP (same clone as 17455-1-PBS)

    WB result of TMEM120A antibody (17455-1-AP; 1:2400; incubated at room temperature for 1.5 hours) with sh-Control and sh-TMEM120A transfected HEK-293 cells. This data was developed using the same antibody clone with 17455-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 17455-1-AP (same clone as 17455-1-PBS)

    IF Staining of HeLa using 17455-1-AP (same clone as 17455-1-PBS)

    Immunofluorescent analysis of HeLa cells using 17455-1-AP (TMEM120A antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 17455-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

TMEM120A Polyclonal antibody, PBS Only

TMEM120A Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 17455-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

Ion channel TACAN, NET29, TACAN, TMPIT, Transmembrane protein 120A

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17455-1-PBS targets TMEM120A in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag10849

Product name: Recombinant human TMEM120A protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-322 aa of BC029487

Sequence: MQPPPPGPLGDCLRDWEDLQQDFQNIQETHRLYRLKLEELTKLQNNCTSSITRQKKRLQELALALKKCKPSLPAEAEGAAQELENRMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILILISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRWAGRALREGSMEWGARTLREAGTGAGGDGGSLLQDQRLVGVPSLRVHLPVGSHADVVRRSHVPEIPEPIPLLFHVPELRAVSPVLLPERLPLPPAGAGRAAHHGPHCGGLPVLDVAGPHLPAAFSFLWTLLAAF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transmembrane protein 120A
别名 Ion channel TACAN, NET29, TACAN, TMPIT, Transmembrane protein 120A
计算分子量 322 aa, 36 kDa, 41 kDa
观测分子量 35 kDa
GenBank蛋白编号BC029487
基因名称 TMEM120A
Gene ID (NCBI) 83862
RRIDAB_2204630
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BXJ8
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TMEM120A (also known as TACAN) is a nuclear envelope transmembrane protein essential for adipocyte differentiation and lipid metabolism. Originally identified through proteomic screening, it regulates spatial genome organization by repositioning pro-adipogenic genes from the nuclear periphery to the interior during adipogenesis. Adipocyte-specific knockout mice exhibit lipodystrophy with insulin resistance. TMEM120A was initially proposed as a mechanosensitive ion channel involved in mechanical pain sensing; however, subsequent structural studies revealed it contains a coenzyme A-binding site and shares homology with fatty acid elongases, challenging its role as an ion channel (PMID: 26024229; 34409941; 34374645).

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