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验证数据展示

  • IHC staining of human tonsillitis using 17766-1-AP (same clone as 17766-1-PBS)

    IHC staining of human tonsillitis using 17766-1-AP (same clone as 17766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 17766-1-AP (TLR3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17766-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 17766-1-AP (same clone as 17766-1-PBS)

    IHC staining of human tonsillitis using 17766-1-AP (same clone as 17766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 17766-1-AP (TLR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17766-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

TLR3/CD283 Polyclonal antibody, PBS Only

TLR3/CD283 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 17766-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, Indirect ELISA

别名

TLR3, CD283, toll like receptor 3, Toll-like receptor 3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17766-1-PBS targets TLR3/CD283 in IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag12171

Product name: Recombinant human TLR3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 26-348 aa of BC094737

Sequence: MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 toll-like receptor 3
别名 TLR3, CD283, toll like receptor 3, Toll-like receptor 3
计算分子量 904 aa, 104 kDa
GenBank蛋白编号BC094737
基因名称 TLR3
Gene ID (NCBI) 7098
RRIDAB_2878436
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO15455
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TLR3 belongs to the Toll-like receptor family which is important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR3 is a nucleotide-sensing TLR that is activated by double-stranded RNA. Upon recognition of dsRNA, TLR3 transmits signals via the adaptor protein TICAM-1/TRIF, leading to the induction of type I IFN, cytokine/chemokine production, and dendritic cell (DC) maturation (PMID: 18262679).

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