TGFBR2 Polyclonal antibody

TGFBR2 Polyclonal Antibody for WB, IHC, ELISA
Cat No. 27212-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human and More (3)

应用

WB, IHC, ELISA

EC:2.7.11.30, TbetaR-II, TGF beta receptor type 2, TGF-beta receptor type II, TGF-beta receptor type-2

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格价格库存


经过测试的应用

Positive WB detected inA549 cells, MCF-7 cells, COLO320 cells
Positive IHC detected inhuman placenta tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

27212-1-AP targets TGFBR2 in WB, IHC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, ELISA Application Description
文献引用应用WB, IHC
经测试反应性 human
文献引用反应性human, mouse, rat, sheep
免疫原

CatNo: Ag25767

Product name: Recombinant human TGFBR2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 23-166 aa of BC040499

Sequence: TIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transforming growth factor, beta receptor II (70/80kDa)
别名 EC:2.7.11.30, TbetaR-II, TGF beta receptor type 2, TGF-beta receptor type II, TGF-beta receptor type-2
计算分子量 65 kDa
观测分子量65-80 kDa
GenBank蛋白编号BC040499
基因名称 TGFBR2
Gene ID (NCBI) 7048
RRIDAB_2918119
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP37173
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TGF beta Receptor II (TGFBR2) is a member of the transforming growth factor-β (TGF-β) superfamily, which are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (PMID: 10974075). TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis (PMID: 29396446). The calculated molecular weight of TGFBR2 is 65 kDa. It has some isoforms with the molecular weight of 70-80 kDa and ~90 kDa after glycosylated.

实验方案

Product Specific Protocols
WB protocol for TGFBR2 antibody 27212-1-APDownload protocol
IHC protocol for TGFBR2 antibody 27212-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Biochim Biophys Acta Mol Cell Res

YWK-II/APLP2 inhibits TGF-β signaling by interfering with the TGFBR2-Hsp90 interaction

Authors - Amannisa Tuersuntuoheti
mouse

Cell Commun Signal

The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα.

Authors - Yumeng Miao
sheepWB

Theriogenology

Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq

Authors - Yongjin Bao
humanWB

Reprod Sci

Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-β2 and TGF-β3.

Authors - Jing Zhang
humanWB

Cell Chem Biol

Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein

Authors - Zhi-Yuan Zhang
mouseWB

Acta Histochem

Inhibition of glutamine transporter ASCT2 mitigates bleomycin-induced pulmonary fibrosis in mice

Authors - Naqi Lian
Loading...