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验证数据展示

  • FC experiment of Transfected HEK-293T using 98667-2-RR (same clone as 98667-2-PBS)

    FC experiment of Transfected HEK-293T using 98667-2-RR (same clone as 98667-2-PBS)

    1x10^6 HEK-293T cells (left) or Tgfbi-transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Mouse TGFBI/BIGH3 Rabbit RecAb (98667-2-RR, Clone:251191C5), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were fixed and permeabilized with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98667-2-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98667-2-RR (same clone as 98667-2-PBS)

    FC experiment of Transfected HEK-293T using 98667-2-RR (same clone as 98667-2-PBS)

    1x10^6 HEK-293T cells(left) or Tgfbi-transfected HEK-293T cells(right) were intracellularly stained with 0.25 ug Anti-Mouse Tgfbi Rabbit RecAb (98667-2-RR, Clone:251191C5) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were fixed and permeabilized with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98667-2-PBS in a different storage buffer formulation.

  • Affinity of 98667-2-RR

    Affinity of 98667-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98667-2-RR against Mouse TGFBI/BIGH3 were performed. The affinity constant is 1.52 nM.

Anti-Mouse TGFBI/BIGH3 Rabbit Recombinant Antibody, PBS Only

TGFBI/BIGH3 Uni-rAb® Recombinant Antibody for FC (Intra)
Cat No. 98667-2-PBS

产品说明书

CloneNo. 251191C5

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC (Intra)

别名

Beta ig-h3, BIGH3, Tgfbi, Transforming growth factor-beta-induced protein ig-h3, βIG-H3

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98667-2-PBS targets TGFBI/BIGH3 in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原

CatNo: Eg3160

Product name: Recombinant Mouse TGFBI/BIGH3 protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 24-683 aa of NM_009369.4

Sequence: GPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETMGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNALRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQFTLLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGMSMETLGGTTLEVGCSGDKLTINGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTAIDILKQAGLDTHLSGKEQLTFLAPLNSVFKDGVPRIDAQMKTLLLNHMVKEQLASKYLYSGQTLDTLGGKKLRVFVYRNSLCIENSCIAAHDKRGRFGTLFTMDRMLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLMEILNREGVYTVFAPTNEAFQAMPPEELNKLLANAKELTNILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSSKNNVVSVNKEPVAETDIMATNGVVYAINTVLQPPANRPQERGDELADSALEIFKQASAYSRAAQRSVRLAPVYQRLLERMKH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transforming growth factor, beta induced
别名 Beta ig-h3, BIGH3, Tgfbi, Transforming growth factor-beta-induced protein ig-h3, βIG-H3
计算分子量75 kDa
GenBank蛋白编号NM_009369.4
基因名称 Tgfbi
Gene ID (NCBI) 21810
RRIDAB_3746258
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP82198
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TGFBI, also named as BIGH3, Kerato-epithelin and RGD-CAP, binds to type I, II, and IV collagens. TGFBI is an adhesion protein which may play an important role in cell-collagen interactions. In cartilage, it may be involved in endochondral bone formation. TGFBI is an extracellular matrix adaptor protein, it has been reported to be differentially expressed in transformed tissues. TGFBI is a predictive factor of the response to chemotherapy, and suggest the use of TGFBI-derived peptides as possible therapeutic adjuvants for the enhancement of responses to chemotherapy.(PMID:20509890) Defects in TGFBI are the cause of epithelial basement membrane corneal dystrophy (EBMD). Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1). Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1). Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB). Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB). Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A). Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD).

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