验证数据展示
产品信息
66842-1-PBS targets TFPI in WB, Indirect ELISA applications and shows reactivity with Human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human |
| 免疫原 | TFPI fusion protein Ag14980 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| 别名 | EPI, Extrinsic pathway inhibitor, LACI, TFI, TFPI, TFPI1 |
| 计算分子量 | 251aa,29 kDa; 304aa,35 kDa |
| 观测分子量 | 35-38 kDa |
| GenBank蛋白编号 | BC015514 |
| 基因名称 | TFPI |
| Gene ID (NCBI) | 7035 |
| RRID | AB_2882183 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P10646 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. TFPI is produced as two major isoforms in humans, TFPIa and TFPIb that result from alternative splicing. The TFPIb isoform localizes to the endothelium surface where it is a potent inhibitor of tissue factor-factor VIIa complexes that initiate blood coagulation. The TFPIa isoform is present in platelets. TFPI is a Kunitz-type serine protease inhibitor that exerts anticoagulant activity by blocking early procoagulant stimulia. TFPI can enhance anti-thrombotic treatment in sepsis, inflammatory diseases, and cardiovascular diseases.
