验证数据展示
产品信息
55307-1-AP targets TET1 in ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | tet oncogene 1 |
| 别名 | CXXC6, KIAA1676, LCX, tet oncogene 1, TET1 |
| 计算分子量 | 235 kDa |
| GenBank蛋白编号 | NM_030625 |
| 基因名称 | TET1 |
| Gene ID (NCBI) | 80312 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q8NFU7 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TET1 ( also named CXXC6, KIAA1676 or LCX), belongs to the TET family (Tet1-3) which catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites of CpG-rich promoters and within genes. Knockdown of Tet1 in preimplantation embryos resulted in a bias towards trophectoderm differentiation.Tet1 can associate with either active or repressed transcriptional states and be identified as new epigenetic factor implicated in the establishment and/or maintenance of a pluripotent epigenetic state during early embryonic development.Tet1 is highly expressed in ES cells and is rapidly downregulated upon differentiation. This antibody is specific to TET1.
