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Host
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Species Reactivity
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Species Reactivity
0
Conjugate
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Conjugate
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Compatible Species
0
Conjugate
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验证数据展示

  • WB analysis of MCF-7 using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of MCF-7 using 66893-1-Ig (same clone as 66893-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of HEK-293 using 66893-1-Ig (same clone as 66893-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of Jurkat using 66893-1-Ig (same clone as 66893-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

  • WB analysis of 4T1 using 66893-1-Ig (same clone as 66893-1-PBS)

    WB analysis of 4T1 using 66893-1-Ig (same clone as 66893-1-PBS)

    4T1 cells were subjected to SDS PAGE followed by western blot with 66893-1-Ig (TERF2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66893-1-PBS in a different storage buffer formulation.

TERF2 Monoclonal antibody, PBS Only

TERF2 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 66893-1-PBS

产品说明书

CloneNo. 5B1E1

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

5B1E1, Telomeric DNA-binding protein, Telomeric repeat-binding factor 2, TRBF2, TRF2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66893-1-PBS targets TERF2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag28513

Product name: Recombinant human TERF2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-251 aa of BC024890

Sequence: MAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTVRLGPSPITMVCP

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 telomeric repeat binding factor 2
别名 5B1E1, Telomeric DNA-binding protein, Telomeric repeat-binding factor 2, TRBF2, TRF2
计算分子量 56 kDa
观测分子量 60-65.32-35 kDa
GenBank蛋白编号BC024890
基因名称 TERF2
Gene ID (NCBI) 7014
RRIDAB_2882222
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDQ15554
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TERF2, also named as TRF2 and Telomeric repeat-binding factor 2, is a 542 amino acid protein, which contains 1 HTH myb-type DNA-binding domain and localizes in the Nucleus. TRF2 binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. TERF2 is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. TERF2 together with DCLRE1B/Apollo, is required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B), which is needed for telomere replication during fork passage and prevent aberrant telomere topology. TERF2 recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. TERF2 exists some isoforms with MV 60 kDa and 32 kDa.