• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

    WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 83236-2-RR (TDO2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83236-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83236-2-RR

    Affinity and Kinetic Characterization of 83236-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83236-2-RR against Human TDO2 were performed. The affinity constant is below 1 pM.

TDO2 Recombinant antibody, PBS Only

TDO2 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA
Cat No. 83236-2-PBS

产品说明书

CloneNo. 240068C2

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, Cytometric bead array, Indirect ELISA

别名

240068C2, EC:1.13.11.11, TDO, TO, TPH2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

产品信息

83236-2-PBS targets TDO2 in WB, Cytometric bead array, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原 TDO2 fusion protein Ag8531 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tryptophan 2,3-dioxygenase
别名 240068C2, EC:1.13.11.11, TDO, TO, TPH2
计算分子量 406 aa, 48 kDa
观测分子量 40-50 kDa
GenBank蛋白编号BC005355
基因名称 TDO2
Gene ID (NCBI) 6999
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP48775
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)