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验证数据展示

  • WB analysis using 12649-1-AP (same clone as 12649-1-PBS)

    WB analysis using 12649-1-AP (same clone as 12649-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12649-1-AP (TCIRG1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12649-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 12649-1-AP (same clone as 12649-1-PBS)

    IF Staining of HepG2 using 12649-1-AP (same clone as 12649-1-PBS)

    Immunofluorescent analysis of HepG2 cells, using TCIRG1 antibody 12649-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). This data was developed using the same antibody clone with 12649-1-PBS in a different storage buffer formulation.

  • WB analysis of A431 using 12649-1-AP (same clone as 12649-1-PBS)

    WB analysis of A431 using 12649-1-AP (same clone as 12649-1-PBS)

    WB result of TCIRG1 antibody (12649-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-TCIRG1 transfected A431 cells. This data was developed using the same antibody clone with 12649-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 12649-1-AP (same clone as 12649-1-PBS)

    IHC staining of human stomach using 12649-1-AP (same clone as 12649-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human normal stomach slide using 12649-1-AP (TCIRG1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12649-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

TCIRG1 Polyclonal antibody, PBS Only

TCIRG1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 12649-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

T-cell immune regulator 1, OPTB1, OC-116 kDa, OC116, ATP6V0A3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12649-1-PBS targets TCIRG1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag3378

Product name: Recombinant human TCIRG1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 25-395 aa of BC018133

Sequence: CVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPTLIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIIT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
别名 T-cell immune regulator 1, OPTB1, OC-116 kDa, OC116, ATP6V0A3
计算分子量 830 aa, 93 kDa
观测分子量 92 kDa, 65-70 kDa
GenBank蛋白编号BC018133
基因名称 TCIRG1
Gene ID (NCBI) 10312
RRIDAB_10644329
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13488
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TCIRG1, also known as V ATPase 116 kDa isoform a3, TIRC7, OPTB1, belongs to the V-ATPase 116 kDa subunit family, TCIRG1 seems to be directly involved in T-cell activation (PubMed:10329006). Alternative splicing results in multiple transcript variants. Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus (PMID: 15809087, 24753205). Mutations in TCIRG1 are associated with Osteopetrosis, autosomal recessive 1 (OPTB1)( PMID: 11532986).

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