验证数据展示
产品信息
CL594-66500 targets WWTR1 in IF applications and shows reactivity with Human, rat, mouse samples.
| 经测试应用 | IF Application Description |
| 经测试反应性 | Human, rat, mouse |
| 免疫原 | WWTR1 fusion protein Ag13330 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | WW domain containing transcription regulator 1 |
| 别名 | DKFZp586I1419, TAZ, WWTR1 |
| 计算分子量 | 44 kDa |
| 观测分子量 | 55 kDa |
| GenBank蛋白编号 | BC014052 |
| 基因名称 | WWTR1 |
| Gene ID (NCBI) | 25937 |
| 偶联类型 | CoraLite® Plus 594 Fluorescent Dye |
| 最大激发/发射波长 | 588 nm / 604 nm |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q9GZV5 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TAZ, also referred as WWTR1, is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 protein. TAZ is expressed in many primary tumors, such as breast cancer, thyroid carcinoma, colorectal cancer, and glioma. TAZ has been reported to be one of the nuclear effectors of Hippo-related pathways that regulate organ size control, cancer stem cell (CSC) properties, and epithelial-mesenchymal transition (EMT). TAZ has been defined for its role in the nucleus, where it functions directly as a transcriptional regulator by interacting with several nuclear factors as Runx2/Cbfa1, NHERF-2, TEF-1, TBX5, PAX3, PAX8 and TTF-1.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 594 WWTR1 antibody CL594-66500 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |