SYNGAP1 Polyclonal antibody

SYNGAP1 Polyclonal Antibody for WB, IHC, IF/ICC, IP, ELISA
Cat No. 19739-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat, pig

应用

WB, IHC, IF/ICC, IP, ELISA

Synaptic Ras-GAP 1, Synaptic Ras GTPase-activating protein 1, RASA 1, Ras/Rap GTPase-activating protein SynGAP, Ras GTPase activating protein SynGAP

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inmouse brain tissue, rat brain tissues, pig brain tissues
Positive IP detected inmouse brain tissue
Positive IHC detected inmouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inU-251 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:4000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

19739-1-AP targets SYNGAP1 in WB, IHC, IF/ICC, IP, ELISA applications and shows reactivity with human, mouse, rat, pig samples.

经测试应用 WB, IHC, IF/ICC, IP, ELISA Application Description
文献引用应用WB, IHC
经测试反应性 human, mouse, rat, pig
文献引用反应性mouse
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 synaptic Ras GTPase activating protein 1 homolog (rat)
别名 Synaptic Ras-GAP 1, Synaptic Ras GTPase-activating protein 1, RASA 1, Ras/Rap GTPase-activating protein SynGAP, Ras GTPase activating protein SynGAP
计算分子量 1343 aa, 148 kDa
观测分子量 148 kDa
GenBank蛋白编号NM_006772
基因名称 SYNGAP1
Gene ID (NCBI) 8831
RRIDAB_10638472
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96PV0
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

SYNGAP1, also named as KIAA1938, is the major constituent of the PSD essential for postsynaptic signaling. It's an inhibitory regulator of the Ras-cAMP pathway. SYNGAP1 is a member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. SYNGAP1 regulates AMPAR-mediated miniature excitatory postsynaptic currents. SYNGAP1 may be involved in certain forms of brain injury, leading to long-term learning and memory deficits Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5).

实验方案

Product Specific Protocols
WB protocol for SYNGAP1 antibody 19739-1-APDownload protocol
IHC protocol for SYNGAP1 antibody 19739-1-APDownload protocol
IF protocol for SYNGAP1 antibody 19739-1-APDownload protocol
IP protocol for SYNGAP1 antibody 19739-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseWB

Front Aging Neurosci

Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.

Authors - Cong-Cong Qi
mouseWB

Neurochem Int

Resveratrol ameliorates learning and memory impairments induced by bilateral hippocampal injection of streptozotocin in mice.

Authors - Ya-Dong Wei
mouseWB,IHC

Eur J Neurosci

SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.

Authors - Sydney Aten
mouseWB

Neuroscience

Further Studies on the Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome

Authors - Shangru Lyu
mouseWB

Mol Neurobiol

SNX17 Mediates Dendritic Spine Maturation via p140Cap

Authors - Qiuyan Cui
mouseWB

J Nutr Biochem

Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline

Authors - Ping Lu
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