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验证数据展示

  • WB analysis using 30443-1-AP (same clone as 30443-1-PBS)

    WB analysis using 30443-1-AP (same clone as 30443-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30443-1-AP (SYNCRIP antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30443-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 30443-1-AP (same clone as 30443-1-PBS)

    IHC staining of mouse kidney using 30443-1-AP (same clone as 30443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 30443-1-AP (SYNCRIP antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SYNCRIP antibody included
  • IF Staining of A431 using 30443-1-AP (same clone as 30443-1-PBS)

    IF Staining of A431 using 30443-1-AP (same clone as 30443-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using SYNCRIP antibody (30443-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 30443-1-PBS in a different storage buffer formulation.

SYNCRIP Polyclonal antibody, PBS Only

SYNCRIP Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 30443-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

Glycine- and tyrosine-rich RNA-binding protein, GRY RBP, GRY-RBP, hnRNP Q, HNRPQ

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SYNCRIP Ready-To-Use IHC Kit. SYNCRIP primary antibody included.

产品信息

30443-1-PBS targets SYNCRIP in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag31509

Product name: Recombinant human SYNCRIP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 382-527 aa of BC032643

Sequence: KAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGQGKGVEAGPDLLQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 synaptotagmin binding, cytoplasmic RNA interacting protein
别名 Glycine- and tyrosine-rich RNA-binding protein, GRY RBP, GRY-RBP, hnRNP Q, HNRPQ
计算分子量 623 aa, 70 kDa
观测分子量62-74 kDa
GenBank蛋白编号BC032643
基因名称 SYNCRIP
Gene ID (NCBI) 10492
RRIDAB_3086317
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO60506
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Synaptotagmin-binding, cytoplasmic RNA-interacting protein(SYNCRIP), also identified as hnRNP Q, involves in mRNA processing mechanisms. It's component of the CRD-mediated complex that promotes MYC mRNA stability. Also it is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. As previously reported, the 65 and 74 kDa proteins corresponded to two isoforms of SYNCRIP produced from alternatively spliced mRNAs (PMID: 15340051).

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