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验证数据展示

  • IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

    IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

    IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

    IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

  • WB analysis using 20366-1-AP (same clone as 20366-1-PBS)

    WB analysis using 20366-1-AP (same clone as 20366-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20366-1-AP (SUZ12 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 20366-1-AP (same clone as 20366-1-PBS)

    WB analysis of HEK-293 using 20366-1-AP (same clone as 20366-1-PBS)

    WB result of SUZ12 antibody (20366-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-SUZ12 transfected HEK-293 cells. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

SUZ12 Polyclonal antibody, PBS Only

SUZ12 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 20366-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

20366-1-PBS targets SUZ12 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 suppressor of zeste 12 homolog (Drosophila)
别名
计算分子量 83 kDa
观测分子量 80-90 kDa
GenBank蛋白编号NM_015355
基因名称 SUZ12
Gene ID (NCBI) 23512
RRIDAB_10694152
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ15022
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SUZ12, also termed CHET9, JJAZ1 or KIAA0160, belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. It is a polycomb group (PcG) protein. SUZ12 is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors.

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