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验证数据展示

  • WB analysis of mouse liver using 12822-1-AP (same clone as 12822-1-PBS)

    WB analysis of mouse liver using 12822-1-AP (same clone as 12822-1-PBS)

    mouse liver tissue were subjected to SDS PAGE followed by western blot with 12822-1-AP (SRRM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12822-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 12822-1-AP (same clone as 12822-1-PBS)

    IP experiment of HeLa using 12822-1-AP (same clone as 12822-1-PBS)

    IP result of anti-SRRM1 (IP:12822-1-AP, 4ug; Detection:12822-1-AP 1:300) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 12822-1-PBS in a different storage buffer formulation.

  • WB analysis using 12822-1-AP (same clone as 12822-1-PBS)

    WB analysis using 12822-1-AP (same clone as 12822-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12822-1-AP (SRRM1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12822-1-PBS in a different storage buffer formulation.

  • IHC staining of human thyroid cancer using 12822-1-AP (same clone as 12822-1-PBS)

    IHC staining of human thyroid cancer using 12822-1-AP (same clone as 12822-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 12822-1-AP (SRRM1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12822-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SRRM1 antibody included
  • IHC staining of mouse cerebellum using 12822-1-AP (same clone as 12822-1-PBS)

    IHC staining of mouse cerebellum using 12822-1-AP (same clone as 12822-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 12822-1-AP (SRRM1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12822-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SRRM1 antibody included
  • Featured Product
  • KD/KO Validated

SRRM1 Polyclonal antibody, PBS Only

SRRM1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 12822-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

160 KD, POP101, Ser/Arg-related nuclear matrix protein, SRm160, SR-related nuclear matrix protein of 160 kDa

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SRRM1 Ready-To-Use IHC Kit. SRRM1 primary antibody included.

产品信息

12822-1-PBS targets SRRM1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag3513

Product name: Recombinant human SRRM1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC036187

Sequence: MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSHSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTQPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 serine/arginine repetitive matrix 1
别名 160 KD, POP101, Ser/Arg-related nuclear matrix protein, SRm160, SR-related nuclear matrix protein of 160 kDa
计算分子量 904 aa, 102 kDa
观测分子量 120-160 kDa
GenBank蛋白编号BC036187
基因名称 SRRM1
Gene ID (NCBI) 10250
RRIDAB_2286613
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8IYB3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SRRM1, also named as SRM160 and POP101, contains one PWI domain and belongs to the splicing factor SR family. As part of pre- and post-splicing multiprotein mRNP complexes, SRRM1 is involved in numerous pre-mRNA processing events. It promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. SRRM1 stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. It binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. SRRM1 binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. SRRM1, a protein of high molecular weight(120-160kd), has a heavy glycosylation level and is normally highly phosphorylated. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SRRM1.

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