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验证数据展示

  • IHC staining of mouse colon using 28046-1-AP (same clone as 28046-1-PBS)

    IHC staining of mouse colon using 28046-1-AP (same clone as 28046-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 28046-1-AP (SON antibody) at dilution of 1:8000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28046-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SON antibody included
  • IHC staining of human thyroid cancer using 28046-1-AP (same clone as 28046-1-PBS)

    IHC staining of human thyroid cancer using 28046-1-AP (same clone as 28046-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 28046-1-AP (SON antibody) at dilution of 1:8000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28046-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SON antibody included
  • IHC staining of human thyroid cancer using 28046-1-AP (same clone as 28046-1-PBS)

    IHC staining of human thyroid cancer using 28046-1-AP (same clone as 28046-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 28046-1-AP (SON antibody) at dilution of 1:8000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28046-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SON antibody included

SON Polyclonal antibody, PBS Only

SON Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 28046-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SON Ready-To-Use IHC Kit. SON primary antibody included.

产品信息

28046-1-PBS targets SON in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag27620

Product name: Recombinant human SON protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 14-182 aa of NM_001291411

Sequence: MVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNES

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 SON DNA binding protein
别名
计算分子量 264 aa
GenBank蛋白编号NM_001291411
基因名称 SON
Gene ID (NCBI) 6651
RRIDAB_3086024
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP18583
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SON, also called C21orf50 and DBP5, is a nuclear speckle-localized protein that shares homology with pre-mRNA splicing accessory factors (PMID: 10950926). It is an RNA-binding protein that acts as an mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites, and specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG (PMID: 20581448; 21504830).

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