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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 85155-4-RR (same clone as 85155-4-PBS)

    WB analysis using 85155-4-RR (same clone as 85155-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85155-4-RR (SOCS3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85155-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85155-4-RR

    Affinity and Kinetic Characterization of 85155-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85155-4-RR against Human SOCS3 were performed. The affinity constant is below 1 pM.

SOCS3 Recombinant antibody, PBS Only

SOCS3 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85155-4-PBS

产品说明书

CloneNo. 242809D7

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

242809D7, ATOD4, CIS3, CIS-3, Cytokine-inducible SH2 protein 3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85155-4-PBS targets SOCS3 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 SOCS3 fusion protein Ag5170 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 suppressor of cytokine signaling 3
别名 242809D7, ATOD4, CIS3, CIS-3, Cytokine-inducible SH2 protein 3
计算分子量 25 kDa
观测分子量 25-30 kDa
GenBank蛋白编号BC060858
基因名称 SOCS3
Gene ID (NCBI) 9021
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO14543
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The suppressor of cytokine signaling (SOCS) family proteins are negative feedback system that inhibits cytokine signal transduction. One of the SOCS family, SOCS3, also named CIS3 and SSI3, is involved in inhibition of JAK/STAT pathway which regulates IL-6 signaling in vivo. SOCS3 can be rapidly trigger by a number of factors including interleukins, IFN-gamma and TNF-alpha. Pathology such as inflammatory response, wound repair and obesity and so on have been linked to SOCS3. Observed MW of SOCS3 is from 22-30 kDa(PMID: 24827536,PMID: 26260587, PMID: 26797799).