验证数据展示
产品信息
25286-1-AP targets SOCS1 in ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag17929 Product name: Recombinant human SOCS1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-211 aa of BC153088 Sequence: MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | suppressor of cytokine signaling 1 |
| 别名 | CIS1, CISH1, JAB, JAK-binding protein, SOCS 1 |
| 计算分子量 | 211 aa, 24 kDa |
| GenBank蛋白编号 | BC153088 |
| 基因名称 | SOCS1 |
| Gene ID (NCBI) | 8651 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O15524 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Suppressor of cytokine signaling 1 (SOCS1) is the prototypical member of the SOCS family and functions in a classic negative-feedback loop to inhibit signaling in response to interferon, interleukin-12 and interleukin-2 family cytokines (PMID: 38947335). SOCS1 not only participates in cell signaling, but also in ubiquitination mediated protein degradation process (PMID: 30761449). SOCS1 is constitutively expressed in the thymus where it plays a vital role in T cell development and homeostasis (PMID: 12705851, PMID:982671).
