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SNX3 Polyclonal antibody

SNX3 Polyclonal Antibody for WB, IHC, IF/ICC, ELISA
Cat No. 10772-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, ELISA and More (2)

Grd19, MCOPS8, Protein SDP3, SDP3, sorting nexin 3

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格价格库存


经过测试的应用

Positive WB detected inCOLO 320 cells, A549 cells, HeLa cells
Positive IHC detected inhuman stomach tissue, human skin cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inHeLa cells, A431 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:200-1:800
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

10772-1-AP targets SNX3 in WB, IHC, IF/ICC, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, ELISA Application Description
文献引用应用WB, IHC, IF, CoIP
经测试反应性 human, mouse, rat
文献引用反应性human, mouse, rat
免疫原 SNX3 fusion protein Ag1160 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sorting nexin 3
别名 Grd19, MCOPS8, Protein SDP3, SDP3, sorting nexin 3
计算分子量 19 kDa
观测分子量 16-20 kDa
GenBank蛋白编号BC008444
基因名称 SNX3
Gene ID (NCBI) 8724
RRIDAB_2192691
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO60493
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

SNX3 is a member of the sorting nexin family of proteins regulating membrane traffic. SNX3 regulates endosomal function through its PX (phox homology)-domain-mediated interaction with PtdIns(3)P (PMID: 11433298). It is a potential regulator of neurite formation and may play an important role in the development and function of the central nervous system (PMID: 19576982; 20817026).

实验方案

Product Specific Protocols
WB protocol for SNX3 antibody 10772-1-APDownload protocol
IHC protocol for SNX3 antibody 10772-1-APDownload protocol
IF protocol for SNX3 antibody 10772-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Nat Cell Biol

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.

Authors - Fergal O'Farrell
  • KD Validated
mouseWB,IHC,IF,CoIP

Acta Pharm Sin B

Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis

Authors - Wenjing Yu
humanWB,IF

Nat Commun

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

Authors - Ian J McGough
  • KD Validated
mouseWB

Environ Int

HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity

Authors - Xiaowei Cong
rat,mouseWB,IF

Cell Death Differ

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Authors - Jing Lu
  • KO Validated
humanWB,IF

Oncogene

EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.

Authors - Esra Cicek
  • KD Validated
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