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验证数据展示

  • WB analysis using 87039-1-RR (same clone as 87039-1-PBS)

    WB analysis using 87039-1-RR (same clone as 87039-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87039-1-RR (SNX27 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87039-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 87039-1-RR (same clone as 87039-1-PBS)

    IHC staining of mouse kidney using 87039-1-RR (same clone as 87039-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 87039-1-RR (SNX27 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87039-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 87039-1-RR (same clone as 87039-1-PBS)

    IHC staining of mouse kidney using 87039-1-RR (same clone as 87039-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 87039-1-RR (SNX27 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87039-1-PBS in a different storage buffer formulation.

  • Affinity of 87039-1-RR

    Affinity of 87039-1-RR

    Biolayer interferometry (BLl) kinetic assays of 87039-1-RR against Human SNX27 were performed. The affinity constant is 0.572 nM.

SNX27 Recombinant monoclonal antibody, PBS Only

SNX27 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 87039-1-PBS

产品说明书

CloneNo. 252134D11

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

KIAA0488, My014, Sorting nexin-27

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87039-1-PBS targets SNX27 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag29226

Product name: Recombinant human SNX27 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-100 aa of BC012184

Sequence: MDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 sorting nexin family member 27
别名 KIAA0488, My014, Sorting nexin-27
计算分子量 61 kDa, 60 kDa, 52 kDa, 28 kDa
观测分子量61 kDa
GenBank蛋白编号BC012184
基因名称 SNX27
Gene ID (NCBI) 81609
RRIDAB_3745293
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ96L92
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Sorting nexin 27 (SNX27), a PDZ domain-containing protein, belongs to the sorting nexin family of proteins. SNX27 promotes the recycling of internalized transmembrane proteins from endosomes to the plasma membrane by linking PDZ-dependent cargo recognition to retromer-mediated transport (PMID: 21602791; 23563491). It has been shown that SNX27 deficiency contributes to synaptic and cognitive deficits by modulating glutamate receptor recycling in Down's syndrome (PMID: 23524343). SNX27 has also been proposed to have a role in regulating β-amyloid (Aβ) generation by modulating γ-secretase activity, which is a molecular mechanism for Aβ-dependent pathogenesis in both Down's syndrome and Down's syndrome (PMID: 25437557).

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