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SNTA1 Polyclonal antibody

SNTA1 Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, WB, ELISA

Conjugate

Unconjugated

Cat No : 13131-1-AP

Print datasheet

Synonyms

Alpha 1 syntrophin, SNT1, SNTA1, Syntrophin 1, TACIP1

验证数据展示

  • WB analysis using 13131-1-AP

    WB analysis using 13131-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 13131-1-AP (SNTA1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

  • IHC staining of mouse heart using 13131-1-AP

    IHC staining of mouse heart using 13131-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 13131-1-AP (SNTA1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse heart using 13131-1-AP

    IHC staining of mouse heart using 13131-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 13131-1-AP (SNTA1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive WB detected inmouse heart tissue, rat heart tissue
Positive IHC detected inmouse heart tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

13131-1-AP targets SNTA1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IHC, WB, ELISA
Tested Reactivity human, mouse, rat
Immunogen SNTA1 fusion protein Ag3820 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
Synonyms Alpha 1 syntrophin, SNT1, SNTA1, Syntrophin 1, TACIP1
Calculated Molecular Weight 505 aa, 54 kDa
Observed Molecular Weight 54 kDa
GenBank Accession NumberBC026215
Gene Symbol SNTA1
Gene ID (NCBI) 6640
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ13424
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

SNTA1, also known as Syntrophin 1, SNT1, is cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. SNTA1 is a signal-transducing adaptor protein and serves as a scaffold for various signaling molecules. Alpha-1 syntrophin contains a PDZ domain, two Pleckstrin homology domains, and a 'syntrophin unique' domain. SNTA1 is the high expression in skeletal muscle and heart (PMID: 8576247, 8612778,). The PDZ domain of SNTA1 has been reported to bind to the C-terminal domain of murine cardiac voltage-gated sodium channels (SkM2) causing altering ion channel activity leading to Long QT syndrome(PMID 19684871, 19862833).

实验方案

Product Specific Protocols
WB protocol for SNTA1 antibody 13131-1-APDownload protocol
IHC protocol for SNTA1 antibody 13131-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols